منابع مشابه
Tumour viruses and innate immunity.
Host cells sense viral infection through pattern recognition receptors (PRRs), which detect pathogen-associated molecular patterns (PAMPs) and stimulate an innate immune response. PRRs are localized to several different cellular compartments and are stimulated by viral proteins and nucleic acids. PRR activation initiates signal transduction events that ultimately result in an inflammatory respo...
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The oncogenic role of viruses in cutaneous neoplasms has been known by humankind for more than a century, when the origin of the common wart, or verruca vulgaris, was attributed to the human papilloma virus (HPV). Currently, virus-induced cutaneous neoplasms may be grouped into solid tumors and lymphoproliferative disorders. HPV, from which various serotypes are now known, each being linked to ...
متن کاملEffects of tumour viruses on cell growth.
Cells in higher organisms, from hydra to human beings, are subject to marvellously precise control of growth, and the loss of this control may lead to cancer. Cultured cells in vitro are also subject to control of growth in a rather crude form, which may nevertheless bear some relation to thesystems operating in vivo in whole organisms. Since tumour viruses modify these growth controls in cultu...
متن کاملLymphomagenicity of recombinant mink cell focus-inducing murine leukemia viruses
Recombinant mink cell focus-inducing (MCF) murine leukemic viruses, as well as ecotropic and xenotropic viruses, were tested for ability to accelerate or cause development of lymphoma in AKR and other strains of mice. Of the three classes of virus isolated from AKR, only the MCF viruses were able to accelerate development of AKR lymphoma. This fully supports the idea that the MCF viruses are th...
متن کاملSnoN functions as a tumour suppressor by inducing premature senescence.
SnoN represses TGF-beta signalling to promote cell proliferation and has been defined as a proto-oncogene partly due to its elevated expression in many human cancer cells. Although the anti-tumourigenic activity of SnoN has been suggested, the molecular basis for this has not been defined. We showed here that high levels of SnoN exert anti-oncogenic activity by inducing senescence. SnoN interac...
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ژورنال
عنوان ژورنال: British Journal of Hospital Medicine
سال: 2016
ISSN: 1750-8460,1759-7390
DOI: 10.12968/hmed.2016.77.10.565